Bio3 Bone/Synthetics

The material for bone regeneration


Synthetic bone graft substitute

Osteoplastic material made of bull bone





Natural osteoplastic material made of highly purified bull bone

Bio3 Bone


Bio3 Bone is a safe, according to BSE, transplantation material from Germany which has no cell elements and protein at all. For Bio3 Bone production a technology of gradual multi-level cleaning of spongy and cortical bone tissue CTS is used together with high-temperature processing method. These production processes permit to remove all organic components from the material and exclude any potential immune reactions onset.

Bio3 Bone 500 -1000 – possesses osteogenic properties and high biological compatibility with strongly marked hydrophilic properties. Due to a three-dimensional porous structure of hydroxiapatite of biological origin (of trabecular and diaphysial tubular bone parts) it promotes angiogenesis, bone marrow stem cell migration as well as fast penetration of blood proteins into micropores which, in their turn, are temporary reservoirs for proteins assembly that precipitate their growth.

Synthetic bone graft substitute Bio3 Synthetics



Bio3 Synthetics 500 – 1000 – it is a safe and secure material. Bone homogeneous structure helps to form new bone tissue and ensures its long-term mechanical stability.

High osteoconductivity of Bio3 Synthetics is achieved due to high porosity (80%) with a pore size of 200 to 800 µm and their interconnected structure.

The high microporosity of Bio3 Synthetics is an ideal framework for accelerating the growth of osteogenic cells and it optimally promotes the regeneration of bone tissue. This material is not less effective than materials derived from bovine bone. It is easy to use and it has good resorbability, retains volume and mechanical stability. Resorption process and material integration has 2 phases: during 3-6 months there is beta-tricalcium phosphate regeneration, and then hydroxyapatite integration.

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