Amplified oral pathogens and small diversity of bacteria admonish about premalignant gastric lesions

A Periodontology Journal gave to the public in its issue in November the results, according to which there is a connection between the pathogenic growth and periodontitis, a chronic illness, that invades gums and mouth cavity. This factor can cause the emergence of premalignant gastritic lesions.

According to the estimation of the Society for Cancer research in America, there could be more than 26 thousand of gastritis and cancer cases with almost 11 thousand deaths. It follows therefrom, that various bacteria can lead to the inflammatory process, which can cause or strengthen the progress of numerous cancer forms (including also gastric cancer).

Regardless of the fact, that such threats as Helicobacter pylori, cigarettes, canned and salt foods had been proved to factor into the progress of gastric cancer, new cases of this illness are still being diagnosed each year independent of the mentioned factors. Experts have hazarded a conjecture that the combination of these pathogenic factors might be a reason for periodontitis and lead to chronic systemic inflammatory process and gastric cancer.

The conducted examination distinguishes the connection between the invasion of periodontic pathogens and possible risks of developing premalignant lesions, as well as chronic gastratrophia, intestinal metaplasia and dysplasy that can indicate the progress of gastritic cancer.

More than 100 persons have been scheduled for the upper endoscopy and histopathological examination, after which 35 have been diagnosed with premalignant lesions of stomach cancer. The other 70 without lesions belong to a control group.

There was a complete research to estimate the periodontal situation among the participants, including the collection of saliva and plaque samples for the evaluation of pathogenic invasion to describe oral microbial variety.

A higher bleeding prevalence, as well as higher pathogenic level and smaller bacterial variety have been detected among the participants with premalignant lesions.

The conclusion implies that the invasion of periodontic pathogenic factors and changed bacterial diversity in the mouth cavity, if its level is lower or higher, may promote the progress of premalignant stomach lesions.

Attained results might be significant for the future treatment of chronic periodontal illnesses in order to prevent gastritic cancer.